If a patient is experiencing severe bone pain due to metastatic cancer, what domain of quality of life is primarily affected?

Severe bone pain due to metastatic cancer significantly impacts the physical domain of quality of life. This domain encompasses aspects such as bodily functions, pain levels, mobility, and overall physical health. In the case of metastatic cancer, bone pain can be debilitating and may limit a patient's ability to perform daily activities, engage in meaningful interactions, or pursue enjoyable pastimes.

While other domains such as emotional, spiritual, and social may also be affected due to the consequences of physical pain, the primary and most direct impact is on physical well-being. Recognizing the profound effect of physical symptoms like pain is critical in palliative care, as it allows for appropriate pain management interventions that can enhance the patient's quality of life.